Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
- 주제(키워드) Saccharomonospora sp. , Marine natural products , Chlorinated secondary metabolites
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Chemistry, Organic
- 설명문(일반) [Le, Tu Cam] Ton Duc Thang Univ, Adv Inst Mat Sci, Lab Adv Mat Chem, Ho Chi Minh City, Vietnam; [Le, Tu Cam] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam; [Katila, Nikita; Park, Songhee; Choi, Hyukjae; Choi, Dong-Young] Yeungnam Univ, Coll Pharm, Gyeongbuk 38541, South Korea; [Lee, Jihye; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Lee, Jihye] REDONE Seoul, Labs Marine New Drugs, Seoul 08594, South Korea; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 PERGAMON-ELSEVIER SCIENCE LTD
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000169548
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.bmcl.2020.127145
- PubMed https://pubmed.ncbi.nlm.nih.gov/32249119
초록/요약
Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of beta-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of A beta (1-40) and A beta (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.
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