Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats
- 주제(키워드) Deep brain stimulation , Intracranial self-stimulation , Medial forebrain bundle , Operant conditioning , Stimulation parameter
- 주제(기타) Neurosciences
- 주제(기타) Neuroimaging
- 주제(기타) Surgery
- 설명문(일반) [Kong, Chanho; Shin, Jaewoo; Koh, Chin-Su; Lee, Jihyeon; Yoon, Min-Sik; Jung, Hyun Ho; Chang, Jin Woo] Yonsei Univ, Dept Neurosurg, Coll Med, 50 Yonsei Ro, Seoul, South Korea; [Shin, Jaewoo; Lee, Jihyeon; Yoon, Min-Sik; Chang, Jin Woo] Yonsei Univ, Brain Korea 21 PLUS Project Med Sci, Coll Med, Seoul, South Korea; [Shin, Jaewoo; Lee, Jihyeon; Yoon, Min-Sik; Chang, Jin Woo] Yonsei Univ, Brain Res Inst, Coll Med, Seoul, South Korea; [Cho, Yoon Kyung; Kim, Soonyoung; Jun, Sang Beom] Ewha Womans Univ, Coll Engn, Dept Elect Engn, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 KARGER
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171916
- 본문언어 영어
- Published As https://dx.doi.org/10.1159/000497151
- PubMed https://pubmed.ncbi.nlm.nih.gov/30933953
초록/요약
Background: The medial forebrain bundle (MFB) is involved in the integration of pleasure and reward. Previous studies have used various stimulation parameters for operant conditioning, though the effectiveness of these parameters has not been systematically studied. Objectives: The purpose of the present study was to investigate the optimal MFB stimulation parameters for controlling the conditioned behavior of rats. Methods: We evaluated four factors, including intensity, frequency, pulse duration, and train duration, to determine the effect of each on lever pressure applied by animals. We further compared burst and tonic stimulation in terms of learning and performance abilities. Results: The number of lever presses increased with each factor. Animals in the burst stimulation group exhibited more lever presses. Furthermore, the average speed in the boxed plus maze among burst stimulation group subjects was higher. Conclusion: We determined the optimal parameters for movement control of animals in operant conditioning and locomotor tasks by adjusting various electrical stimulation parameters. Our results reveal that a burst stimulation is more effective than a tonic stimulation for increasing the moving speed and number of lever presses. The use of this stimulation technique also allowed us to minimize the training required to control animal behavior. (C) 2019 S. Karger AG, Basel
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