Clinical features and prognosis of patients with idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
- 주제(키워드) chronic obstructive pulmonary fibrosis , IPF , prognosis
- 주제(기타) Infectious Diseases
- 주제(기타) Respiratory System
- 설명문(일반) [Lee, S. H.] Yonsei Univ, Coll Med, Seoul, South Korea; [Lee, S. H.; Park, J. S.] Seoul Natl Univ, Bundang Hosp, Div Pulm & Crit Care Med, Dept Internal Med,Natl Univ Coll Med, Seoul, South Korea; [Kim, S. Y.; Park, M. S.] Yonsei Univ, Inst Chest Dis, Severance Hosp, Div Pulmonol,Dept Internal Med,Coll Med, 50-1 Yonsei Ro, Seoul 120752, South Korea; [Kim, D. S.; Song, J. W.] Univ Ulsan, Asan Med Ctr, Coll Med, Div Pulm & Crit Care Med, Seoul, South Korea; [Kim, Y. W.] Seoul Natl Univ, Coll Med, Div Pulm & Crit Care Med, Dept Internal Med, Seoul, South Korea; [Kim, Y. W.] Seoul Natl Univ, Coll Med, Lung Inst, Seoul, South Korea; [Chung, M. P.] Sungkyunkwan Univ, Samsung Med Ctr, Div Pulm & Crit Care Med, Sch Med, Seoul, South Korea; [Uh, S. T.] Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Allergy & Resp Med, Seoul, South Korea; [Park, C. S.; Park, S. W.] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Allergy & Resp Med, Gyeonggi Do, South Korea; [Jeong, S. H.] Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Pulmonol, Incheon, South Korea; [Park, Y. B.] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; [Lee, H. L.] Inha Univ Hosp, Dept Internal Med, Pulm Div, Incheon, South Korea; [Shin, J. W.] Chung Ang Univ, Dept Internal Med, Div Pulm Med, Coll Med, Seoul, South Korea; [Lee, J. H.] Ewha Womans Univ, Ewha Med Res Inst, Dept Internal Med, Sch Med, Seoul, South Korea; [Jegal, Y.] Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Div Pulm Med,Coll Med, Ulsan, South Korea; [Lee, H. K.] Inje Univ, Dept Internal Med, Div Crit Care & Pulm Med, Pusan Paik Hosp, Busan, South Korea; [Kim, Y. H.] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Internal Med, Div Allergy & Pulmonol,Sch Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171928
- 본문언어 영어
- Published As https://dx.doi.org/10.5588/ijtld.18.0194
- PubMed https://pubmed.ncbi.nlm.nih.gov/31315699
초록/요약
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) share common risk factors. They could therefore be expressed in a single patient. However, the prevalence, clinical characteristics and prognosis of individuals with comorbid IPF and COPD are not known. METHOD: From 2003 to 2007, the Korean Interstitial Lung Disease Study Group created a register for idiopathic interstitial pneumonia using 2002 ATS/ERS (American Thoracic Society/European Respiratory Society) criteria. Of the 1546 IPF patients assessed, 143 had decreased lung function consistent with COPD (IPF-COPD). COPD was diagnosed based on age (>= 40 years) and pulmonary function (forced expiratory volume in 1 sec [FEV1]/forced vital capacity [FVC] ratio < 0.7). RESULTS : The median age of the IPF-COPD group was 71.0 years (interquartile range 66.0-76.0); most patients were male (88.1%). FVC (%) was significantly higher in the IPF-COPD group; however, FEV1 (%) was significantly lower in the IPF-COPD group (P < 0.001). Diffusing capacity of the lung for carbon monoxide (DLCO) was not significantly different between the two groups. In survival analysis, age and FVC (%), but not COPD, were significantly associated with prognosis (respectively P = 0.003, 0.001 and 0.401). COPD severity was also not related to prognosis (P = 0.935). CONCLUSION: The prevalence of IPF-COPD was estimated to be similar to 9.2% among all IPF patients; prognosis of patients with IPF-COPD was not worse than those with IPF alone.
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