Tonsil-derived stem cells as a new source of adult stem cells
- 주제(키워드) Stem cell , Tonsil-derived stem cell , Differentiation , Endoderm , Mesoderm , Ectoderm , Cell therapy
- 주제(기타) Cell & Tissue Engineering
- 주제(기타) Cell Biology
- 설명문(일반) [Cho, Kyung-Ah] Ewha Womans Univ, Coll Med, Dept Microbiol, Seoul 07985, South Korea; [Lee, Hyun Jung; Jeong, Byeongmoon] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Jeong, Hansaem; Kim, Miri; Lee, Seung Jin; Lee, Hyukjin] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Jung, Soo Yeon; Kim, Han Su] Ewha Womans Univ, Coll Med, Dept Otorhinolaryngol, Ahnyangcheon Ro 1071, Seoul 07985, South Korea; [Park, Hae Sang] Hallym Univ, Coll Med, Dept Otorhinolaryngol, Chunchon 24252, South Korea; [Ryu, Kyung-Ha] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, hybrid, Green Submitted
- 발행기관 BAISHIDENG PUBLISHING GROUP INC
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171937
- 본문언어 영어
- Published As https://dx.doi.org/10.4252/wjsc.v11.i8.506
- PubMed https://pubmed.ncbi.nlm.nih.gov/31523370
초록/요약
Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, T-SCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.
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