A simple decontamination procedure for unintended iodide impurity during [C-11]methionine production
- 주제(키워드) L-[S-methyl-C-11]methionine , Iodine impurity , [C-11]Radiopharmaceuticals , Anion-exchange resin cartridge
- 주제(기타) Chemistry, Analytical
- 주제(기타) Chemistry, Inorganic & Nuclear
- 주제(기타) Nuclear Science & Technology
- 설명문(일반) [Park, Hyun Sik; Lee, Hong Jin; An, Hyun Ho; Lee, Won Woo; Kim, Sang Eun; Lee, Byung Chul] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Nucl Med, Seongnam 13620, South Korea; [Moon, Byung Seok; Kim, Bom Sahn] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Nucl Med, Seoul 07804, South Korea; [Kim, Sang Eun; Lee, Byung Chul] Adv Inst Convergence Technol, Ctr Nanomol Imaging & Innovat Drug Dev, Suwon 16229, South Korea; [Kim, Sang Eun] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Transdisciplinary Studies, Seoul 08826, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171946
- 본문언어 영어
- Published As https://dx.doi.org/10.1007/s10967-019-06757-6
초록/요약
A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [C-11]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [C-11]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [C-11]methionine solution using an anion-exchange resin cartridge.
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