Clinical significance of focal ss-amyloid deposition measured by F-18-flutemetamol PET
- 주제(키워드) ss-amyloid , F-18-flutemetamol PET , Alzheimer's disease , Cognition , Cerebrospinal fluid
- 주제(기타) Clinical Neurology
- 주제(기타) Neurosciences
- 설명문(일반) [Kim, Si Eun; Park, Seongbeom; Cho, Soo Hyun; Kim, Seung Joo; Jang, Hyemin; Na, Duk L.; Seo, Sang Won; Kim, Hee Jin] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, 50 Ilwon Dong, Seoul 135710, South Korea; [Kim, Si Eun] Inje Univ, Haeundae Paik Hosp, Dept Neurol, Coll Med, Busan, South Korea; [Lee, Byungju] Yuseong Geriatr Rehabil Hosp, Dept Neurol, Pohang, South Korea; [Park, Seongbeom; Jang, Hyemin; Na, Duk L.; Seo, Sang Won; Kim, Hee Jin] Samsung Med Ctr, Samsung Alzheimer Res Ctr, Seoul, South Korea; [Park, Seongbeom; Jang, Hyemin; Na, Duk L.; Seo, Sang Won; Kim, Hee Jin] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea; [Cho, Soo Hyun] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Med Sch, Gwangju, South Korea; [Kim, Seung Joo] Gyeongsang Natl Univ, Dept Neurol, Sch Med, Chang Won, South Korea; [Kim, Seung Joo] Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea; [Kim, Yeshin; Jang, Jae-Won] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Neurol, Coll Med, Chunchon, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Neurol, Seoul, South Korea; [Yoon, Soo Jin] Eulji Univ, Eulji Univ Hosp, Dept Neurol, Sch Med, Daejeon, South Korea; [Park, Kyung Won] Dong A Univ, Dept Neurol, Coll Med, Dong A Med Ctr, Busan, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Neurol, Sch Med, Busan, South Korea; [Kim, Eun-Joo] Med Res Inst, Busan, South Korea; [Jung, Na Yeon] Pusan Natl Univ, Yangsan Hosp, Dept Neurol, Sch Med, Yangsan, South Korea; [Jung, Na Yeon] Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea; [Yoon, Bora] Konyang Univ, Dept Neurol, Coll Med, Daejeon, South Korea; [Hong, Jin Yong] Yonsei Univ, Wonju Coll Med, Dept Neurol, Wonju, South Korea; [Hwang, Jihye] Keimyung Univ, Daegu Dongsan Hosp, Dept Neurol, Daegu, South Korea; [Na, Duk L.] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul, South Korea; [Na, Duk L.] Samsung Med Ctr, Stem Cell & Regenerat Med Inst, Seoul, South Korea; [Seo, Sang Won] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea; [Seo, Sang Won] Samsung Med Ctr, Ctr Clin Epidemiol, Seoul, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 BMC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171950
- 본문언어 영어
- Published As https://dx.doi.org/10.1186/s13195-019-0577-x
- PubMed https://pubmed.ncbi.nlm.nih.gov/31901233
초록/요약
Background Although amyloid PET of typical Alzheimer's disease (AD) shows diffuse ss-amyloid (Ass) deposition, some patients show focal deposition. The clinical significance of this focal Ass is not well understood. We examined the clinical significance of focal Ass deposition in terms of cognition as well as Ass and tau cerebrospinal fluid (CSF) levels. We further evaluated the order of Ass accumulation by visual assessment. Methods We included 310 subjects (125 cognitively unimpaired, 125 mild cognitive impairment, and 60 AD dementia) from 9 referral centers. All patients underwent neuropsychological tests and F-18-flutemetamol (FMM) PET. Seventy-seven patients underwent CSF analysis. Each FMM scan was visually assessed in 10 regions (frontal, precuneus and posterior cingulate, lateral temporal, parietal, and striatum of each hemisphere) and was classified into three groups: No-FMM, Focal-FMM (FMM uptake in 1-9 regions), and Diffuse-FMM (FMM uptake in all 10 regions). Results 53/310 (17.1%) subjects were classified as Focal-FMM. The cognitive level of the Focal-FMM group was better than that of Diffuse-FMM group and worse than that of No-FMM group. Among the Focal-FMM group, those who had FMM uptake to a larger extent or in the striatum had worse cognitive levels. Compared to the Diffuse-FMM group, the Focal-FMM group had a less AD-like CSF profile (increased Ass42 and decreased t-tau, t-tau/Ass42). Among the Focal-FMM group, Ass deposition was most frequently observed in the frontal (62.3%) and least frequently observed in the striatum (43.4%) and temporal (39.6%) regions. Conclusions We suggest that focal Ass deposition is an intermediate stage between no Ass and diffuse Ass deposition. Furthermore, among patients with focal Ass deposition, those who have Ass to a larger extent and striatal involvement show clinical features close to diffuse Ass deposition. Further longitudinal studies are needed to evaluate the disease progression of patients with focal Ass deposition.
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