Ordered assemblies of Fe3O4 and a donor-acceptor-type pi-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects
- 주제(키워드) Conjugated polymers , Iron oxides , Hybrid nanoparticles , Photoacoustic imaging , Magnetic resonance imaging
- 주제(기타) Polymer Science
- 설명문(일반) [Thi-Thuy Duong Pham; Lee, Dabin; Noh, Juran; Chae, Jeongwan; Kang, Eunah; Park, Juhyun] Chung Ang Univ, Inst Energy Converting Soft Mat, Sch Chem Engn & Mat Sci, Seoul 06974, South Korea; [Seo, Young Hun; Kim, Sehoon] Korea Inst Sci & Technol, Ctr Theragnosis, Seoul 02792, South Korea; [Park, JaeHong] Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan; [Shin, Tae Joo] UNIST, UNIST Cent Res Facil, Ulsan 44919, South Korea; [Shin, Tae Joo] UNIST, Sch Nat Sci, Ulsan 44919, South Korea; [Kim, Sehoon] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171971
- 본문언어 영어
- Published As https://dx.doi.org/10.1016/j.polymer.2018.12.020
초록/요약
We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe3O4) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe3O4) exhibited the shortest transversal relaxation time, T-2, and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.
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