Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells
- 주제(키워드) cytotoxicity , organelles , photodynamic therapy , photosensitizers , singlet oxygen
- 주제(기타) Chemistry, Physical
- 설명문(일반) [Ucar, Esma; Akkaya, Engin U.] Bilkent Univ, Dept Chem, TR-06800 Ankara, Turkey; [Seyen, Ozlem; Akkaya, Engin U.] Bilkent Univ, UNAM, Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey; [Lee, Dayoung; Kim, Gyoungmi; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Akkaya, Engin U.] Dalian Univ Technol, State Key Lab Fine Chem, Sch Pharmaceut Sci & Technol, Dalian 116024, Peoples R China
- 등재 SCIE
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000171980
- 본문언어 영어
- Published As https://dx.doi.org/10.1002/cptc.201800231
초록/요약
Among the pathways for improving the practice of photodynamic therapy of cancer, increasing the selectivity of photodynamic action is an obvious choice. Considering the different characteristics of mitochondria in normal cells and cancer cells, we designed mitochondria-targeting photosensitizers. We now demonstrate for the first time that mitochondria-targeted photosensitizers by triphenylphosphonium (TPP) derivatization are more selective for cancer cells compared to normal cells, presumably due to the larger membrane potential of cancer-cell mitochondria allowing more efficient accumulation of the photosensitizer.
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