Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface
- 주제(키워드) Ceramide , Click chemistry , Liposomes , Membrane fusion , Triazole
- 주제(기타) Chemistry, Organic
- 설명문(일반) [Lee, Seokwoo; Lee, Yun Mi; Lee, Hyun-Ji; Jeon, Hongjun; Kim, Sanghee] Seoul Natl Univ, Coll Pharm, 1 Gwanak Ro, Seoul 08826, South Korea; [Lee, Hyukjin] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Shin, Dongyun] Gachon Univ, Coll Pharm, 191 Hambakmoe Ro, Incheon 21936, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172018
- 본문언어 영어
- Published As https://dx.doi.org/10.1002/ajoc.201900342
초록/요약
An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.
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