Auranofin is an effective agent against clinical isolates of Staphylococcus aureus
- 주제(키워드) antimicrobial , auranofin , drug resistant bacteria , MRSA , Staphylococcus aureus , thioredoxin reductase , VISA
- 주제(기타) Chemistry, Medicinal
- 설명문(일반) [Tharmalingam, Nagendran; Ribeiro, Noelly Q.; da Silva, Danielle L.; Cruz, Lana I. B.; Kim, Wooseong; Shen, Steven; Ezikovich, Katarina; D'Agata, Erika M. C.; Mylonakis, Eleftherios; Fuchs, Beth B.] Rhode Isl Hosp, Alpert Med Sch, Div Infect Dis, Dept Med, Providence, RI 02903 USA; [Tharmalingam, Nagendran; Ribeiro, Noelly Q.; da Silva, Danielle L.; Cruz, Lana I. B.; Kim, Wooseong; Shen, Steven; Ezikovich, Katarina; D'Agata, Erika M. C.; Mylonakis, Eleftherios; Fuchs, Beth B.] Brown Univ, Providence, RI 02903 USA; [Ribeiro, Noelly Q.; da Silva, Danielle L.; Cruz, Lana I. B.] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil; [Naik, Mandar T.] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02903 USA; [dos Santos, Jessica D.] Univ Estadual Paulista, Dept Biosci & Oral Diag, UNESP, Sao Jose Dos Campos, SP, Brazil
- 등재 SCIE, SCOPUS
- 발행기관 FUTURE SCI LTD
- 발행년도 2019
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172032
- 본문언어 영어
- Published As https://dx.doi.org/10.4155/fmc-2018-0544
초록/요약
Aim: The orphan drug auranofin was recently found to exhibit antimicrobial properties. Materials & methods: We explored the efficacy of auranofin by evaluating the minimal inhibitory concentration against a collection of over 500 clinical isolates derived from multiple institutions, inclusive of drug resistant strains. Our evaluation also included continuous exposure of bacteria to auranofin. Results & conclusion: We found that minimal inhibitory concentrations ranged between 0.125 and 1 mg/l, exerting robust antimicrobial activity against a sizeable clinical collection of the bacteria. Further, we evaluated the propensity of the methicillin resistant Staphylococcus aureus strain MW2 to develop resistance through extended exposure to auranofin. After 25 days, the bacteria remained susceptible. Our data suggest that resistance mechanisms do not currently exist to block auranofin antimicrobial activity.
more