The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover
- 주제(키워드) alcohol , hangover , ethanol , acetaldehyde , acetate , oxidative stress , malondialdehyde , 8-isoprostane , cytokines , C-reactive protein
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [van de Loo, Aurora J. A. E.; Mackus, Marlou; Garssen, Johan; Kraneveld, Aletta D.; Verster, Joris C.] Univ Utrecht, Utrecht Inst Pharmaceut Sci UIPS, Div Pharmacol, NL-3584 CG Utrecht, Netherlands; [van de Loo, Aurora J. A. E.; Verster, Joris C.] Univ Utrecht, Inst Risk Assessment Sci IRAS, NL-3584 CM Utrecht, Netherlands; [Kwon, Oran; Verster, Joris C.] Ewha Womans Univ, Dept Nutr Sci & Food Management, BioFood Lab, BioFood Network, Seoul 120750, South Korea; [Krishnakumar, Illathu Madhavamenon] Akay Nat Ingredients Private Ltd, Cochin 683561, Kerala, India; [Garssen, Johan] Nutricia Danone Res, Global Ctr Excellence Immunol, NL-3584 CT Utrecht, Netherlands; [Scholey, Andrew] Swinburne Univ, Ctr Human Psychopharmacol, Melbourne, Vic 3122, Australia
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000172349
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/jcm9072081
- PubMed https://pubmed.ncbi.nlm.nih.gov/32630717
초록/요약
An increasing number of studies are focusing on the inflammatory response to alcohol as a potentially important determinant of hangover severity. In this article, data from two studies were re-evaluated to investigate the relationship between hangover severity and relevant biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol. Hangover severity was significantly and positively correlated with blood concentrations of biomarkers of the inflammatory response to alcohol, in particular, Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. In addition, biomarkers of oxidative stress, i.e., malondialdehyde and 8-isoprostrane, were significantly correlated with hangover severity, suggesting that oxidative stress also contributes to the inflammatory response. The timing of the assessments suggests initial slow elimination of ethanol in the first hours after alcohol consumption. As a consequence, more ethanol is present in the second half of the night and the next morning, which will elicit more oxidative stress and a more profound inflammatory response. Together, these processes result in more severe hangovers.
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