The fruit of Acanthopanax senticosus Harms improves arterial stiffness and blood pressure: a randomized, placebo-controlled trial
- 주제(키워드) Vascular stiffness , cardiovascular diseases , Acanthopanax , pulse wave velocity , endothelial nitric oxide synthase
- 주제(기타) Nutrition & Dietetics
- 설명문(일반) [Oh, Eunkyoung; Kim, Youjin; Park, Soo-yeon; Lim, Yeni; Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Shin, Ji-yoon] Ewha Grad Sch Converging Clin & Publ Hlth, Seoul 03760, South Korea; [Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea; [Kim, Ji-Hyun; Rhee, Moo-Yong] Dongguk Univ, Ilsan Hosp, Cardiovasc Ctr, Goyang 10326, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN NUTRITION SOC
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000172353
- 본문언어 영어
- Published As https://dx.doi.org/10.4162/nrp.2020.14.4.322
- PubMed https://pubmed.ncbi.nlm.nih.gov/32765813
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
BACKGROUND/OBJECTIVES: Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acumhopcmax senticosus Harms (ASH) is a traditional medicinal plant that can improve cardiovascular health. This study aimed to investigate the efficacy of the fruit of ASH on vascular function in apparently healthy subjects. SUBJECTS/METHODS: A 12-week, randomized, double-blind, placebo-controlled design, consisting of healthy adults with at least 2 of the following 3 conditions: borderline high blood pressure (BP; 120 mmHg <= systolic BP <= 160 mmHg or 80 mmHg <= diastolic BP <= 100 mmHg), smoking (>= 10 cigarettes/day), and borderline blood lipid levels (220 <= total cholesterol 240, 130 5 low density lipoprotein cholesterol <= 165, or 150 <= triglyceride <= 220 mg/dL). Randomly assigned 76 subjects who received a placebo or 2 doses of ASH fruit (low, 500 mg/day; high, 1,000 mg/day) completed the intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, and BP were measured both at baseline and following the 12-week intervention. Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting. RESULTS: Compared with the placebo group, the low-dose group showed more significant changes after the 12-week intervention period in terms of systolic BP (0.1 vs. -7.7 mmHg; P= 0.044), baPWV (31.3 vs. -98.7 cm/s; P= 0.007), and the ratio of phospho-eNOS/eNOS (0.8 vs. 1.22; P= 0.037). CONCLUSIONS: These results suggest that ASH fruit extract at 500 mg/day has the potential to improve BP and arterial stiffness via endothelial eNOS activation in healthy adults with smoking and the tendency of having elevated BP or blood lipid parameters.
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