Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies
- 주제(키워드) radiation , lung fibrosis , animal models , antifibrotic , therapeutic targets
- 주제(기타) Oncology
- 설명문(일반) [Jin, Hee; Yoo, Youngjo; Kim, Younghwa; Kim, Yeijin; Lee, Yun-Sil] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Jin, Hee; Yoo, Youngjo; Kim, Younghwa; Kim, Yeijin; Lee, Yun-Sil] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Cho, Jaeho] Yonsei Univ Hlth Syst, Dept Radiat Oncol, Seoul 03722, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172373
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/cancers12061561
- PubMed https://pubmed.ncbi.nlm.nih.gov/32545674
초록/요약
Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation, and differentiation of fibroblasts and, finally, results in excessive extracellular matrix deposition. Currently, there are no approved treatment options for patients with radiation-induced pulmonary fibrosis (RIPF) partly due to the absence of effective targets. Current research advances include the development of small animal models reflecting modern radiotherapy, an understanding of the molecular basis of RIPF, and the identification of candidate drugs for prevention and treatment. Insights provided by this research have resulted in increased interest in disease progression and prognosis, the development of novel anti-fibrotic agents, and a more targeted approach to the treatment of RIPF.
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