Marine natural products with monoamine oxidase (MAO) inhibitory activity
- 주제(키워드) MAOIs , aplysinopsins , piloquinones , anithiactins , bromopyrroles , caulerpins , astaxanthin
- 주제(기타) Plant Sciences
- 주제(기타) Medical Laboratory Technology
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Hong, Ahreum; Lim, Kyung-Min] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea; [Tu, Le Cam] Ton Duc Thang Univ, Adv Inst Mat Sci, Lab Adv Mat Chem, Ho Chi Minh City, Vietnam; [Tu, Le Cam] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 TAYLOR & FRANCIS LTD
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172384
- 본문언어 영어
- Published As https://dx.doi.org/10.1080/13880209.2020.1790618
- PubMed https://pubmed.ncbi.nlm.nih.gov/32697127
초록/요약
Context Research interest in monoamine oxidase (MAO) as a promising drug target for neurodegenerative diseases has a long history. However, efforts to develop MAO inhibitors (MAOIs) from marine sources have been limited, despite the increasing number of interesting marine natural products. Objective To review the potential of marine natural products as MAOIs source, including their activities and selectivity on MAO. Methods Public databases such as SciFinder, MarinLit and PubMed were systematically searched from 1991 until Dec 2019. MAO and MAOI were the key terms searched combined with marine natural products and marine. Results Six classes of marine natural products with good selectivity between the two MAO subtypes were organized with their selectivity and sources. Conclusions This is the first review to investigate the potential of marine natural products as MAOIs source. Despite the small number of known MAOIs from marine sources, marine natural products are potential leads for the further development of MAOI drugs with novel chemical frames and good selectivity.
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