Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study
- 주제(키워드) Crohn's disease , prognosis , microbiota
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Park, Soo-kyung; Park, Dong Il] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Gastroenterol,Sch Med, Seoul 03181, South Korea; [Park, Soo-kyung; Kim, Han-Na; Lee, Chil-Woo; Park, Dong Il] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul 03181, South Korea; [Park, Soo-kyung; Choi, Chang Hwan; Im, Jong Pil; Kim, Tae-Oh; Yoon, Hyuk; Park, Dong Il] Korean Assoc Study Intestinal Dis, Inflammatory Bowel Dis Study Grp, Seoul 06193, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul 03063, South Korea; [Choi, Chang Hwan] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul 06973, South Korea; [Im, Jong Pil] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 03080, South Korea; [Im, Jong Pil] Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul 03080, South Korea; [Cha, Jae Myung] Kyung Hee Univ, Dept Internal Med, Sch Med, Kyung Hee Univ Hosp Gang Dong, Seoul 02447, South Korea; [Eun, Chang Soo; Han, Dong-Soo] Hanyang Univ, Dept Internal Med, Guri Hosp, Guri 11923, South Korea; [Kim, Tae-Oh] Inje Univ, Dept Internal Med, Div Gastroenterol, Haeundae Paik Hosp, Busan 48108, South Korea; [Kang, Sang-Bum] Catholic Univ Korea, Daejeon St Marys Hosp, Dept Internal Med, Div Gastroenterol, Daejeon 34943, South Korea; [Bang, Ki Bae] Dankook Univ, Dept Internal Med, Coll Med, Cheonan 31116, South Korea; [Kim, Hyun Gun] Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Seoul 04401, South Korea; [Jung, Yunho] Soonchunhyang Univ, Cheonan Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Cheonan 31151, South Korea; [Yoon, Hyuk] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam 13620, South Korea; [Ahn, Kwangsung] PDXen Biosyst Inc, Funct Genome Inst, Daejeon 34129, South Korea; [Kim, Hyung-Lae] Ewha Womans Univ, Sch Med, Dept Biochem, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000172396
- 본문언어 영어
- Published As https://dx.doi.org/10.3390/jcm9061748
- PubMed https://pubmed.ncbi.nlm.nih.gov/32516912
초록/요약
Limited studies have examined the intestinal microbiota composition in relation to Crohn's disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota alpha-diversity decreased more in CD-P than CD-G and CD-I. Microbiota ss-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups.Escherichia coli(p= 0.001) and speciesProducta(p= 0.01) and generaLactobacillus(p= 0.003) and Coprococcus (p= 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, andE. coliwere the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, andE. colimight be causally involved in CD progression, and may have adapted to live in inflammatory environments.
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