Spatiotemporal Regulation ofVibrioExotoxins by HlyU and Other Transcriptional Regulators
- 주제(키워드) exotoxin , transcriptional regulation , hemolysin , cytolysin , MARTX toxin , secreted phospholipase , HlyU , Vibriospecies
- 주제(기타) Food Science & Technology
- 주제(기타) Toxicology
- 설명문(일반) [Kim, Byoung Sik] Ewha Womans Univ, ELTEC Coll Engn, Dept Food Sci & Engn, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174507
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/toxins12090544
- PubMed https://pubmed.ncbi.nlm.nih.gov/32842612
초록/요약
After invading a host, bacterial pathogens secrete diverse protein toxins to disrupt host defense systems. To ensure successful infection, however, pathogens must precisely regulate the expression of those exotoxins because uncontrolled toxin production squanders energy. Furthermore, inappropriate toxin secretion can trigger host immune responses that are detrimental to the invading pathogens. Therefore, bacterial pathogens use diverse transcriptional regulators to accurately regulate multiple exotoxin genes based on spatiotemporal conditions. This review covers three major exotoxins in pathogenicVibriospecies and their transcriptional regulation systems. WhenVibrioencounters a host, genes encoding cytolysin/hemolysin, multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin, and secreted phospholipases are coordinately regulated by the transcriptional regulator HlyU. At the same time, however, they are distinctly controlled by a variety of other transcriptional regulators. How this coordinated but distinct regulation of exotoxins makesVibriospecies successful pathogens? In addition, anti-virulence strategies that target the coordinating master regulator HlyU and related future research directions are discussed.
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