Left ventricular response after cardiac resynchronization therapy is related to early left atrial volume reduction
- 주제(키워드) Atrial remodeling , Ventricular remodeling , Cardiac resynchronization therapy
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Cho, In-Jeong] Ewha Womans Univ, Dept Internal Med, Div Cardiol, Seoul Hosp, Seoul, South Korea; [Uhm, Jae-Sun; Oh, Jaewon; Nam, Jong-Ho; Yu, Hee Tae; Kim, Taehoon; Joung, Boyoung; Kang, Seok-Min] Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Div Cardiol,Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN ASSOC INTERNAL MEDICINE
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174528
- 본문언어 영어
- Published As http://dx.doi.org/10.3904/kjim.2018.430
- PubMed https://pubmed.ncbi.nlm.nih.gov/32019293
초록/요약
Background/Aims: The current study aimed to elucidate a time-course change in left atrial volume after cardiac resynchronization therapy (CRT) and to verify factors associated with left atrial volume reduction (LAVR) and its prognostic implications. Methods: The records of 97 patients were retrospectively reviewed after CRT. Echocardiographic data were analyzed at baseline before CRT, at early follow-up (FU) (<= 1 year, median 6 months), and at late FU (median 30 months). Left ventricular volume response (LVVR) was defined as 15% reduction in left ventricular (LV) end-systolic volume (ESV). LAVR was classified into two groups by the median value at early FU: LAVR (>= 7.5%) and no LAVR (< 7.5%). Results: LV ESV index continuously decreased from baseline to early FU and from early FU to late FU (106.1 +/- 47.4 mL/m(2) vs. 87.6 +/- 51.6 mL/m(2) vs. 72.5 +/- 57.1 mL/m(2)) LA volume index decreased from baseline to early FU, but there were no reductions thereafter (51.8 +/- 21.9 mL/m(2) vs. 45.1 +/- 19.6 mL/m(2) vs. 44.9 +/- 23.0 The only echocardiographic factor associated with LAVR was change in E velocity (odds ratio [OR], 1.04; p = 0.002). Early LAVR (OR, 10.05; p = 0.002) was an indepen-dent predictor for late LVVR. Conclusions: LAVR was related to reduction in E velocity, suggesting its relation with optimization of LV filling pressure. Early LAVR was a predictor for LVVR to CRT in long-term FU.
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