Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice
- 주제(키워드) peroxiredoxin V , reactive oxygen species , renal ischemia , reperfusion , renal dysfunction
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Food Science & Technology
- 설명문(일반) [Park, Jiyoung; Lee, Eun Gyeong; Kim, Nam Hee; Woo, Hyun Ae] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 120750, South Korea; [Yi, Ho Jin; Woo, Hyun Ae] Ewha Womans Univ, Coll Pharm, Grad Sch Appl Sci & Technol Skin Hlth & Aesthet, Seoul 120750, South Korea; [Rhee, Sue Goo] Yonsei Univ, Yonsei Biomed Res Inst, Coll Med, Seoul 120752, South Korea; [Rhee, Sue Goo] NHLBI, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174540
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/antiox9080769
- PubMed https://pubmed.ncbi.nlm.nih.gov/32824836
초록/요약
Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury.
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