Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
- 주제(키워드) sarmentosamide , Streptomyces sp. , APmarine042 , anti-aging , MMP-1 , UVB , TNF-alpha
- 주제(기타) Chemistry, Medicinal
- 설명문(일반) [Lee, Eun-Soo; Ko, Jaeyoung] Amorepacif Corp R&D Ctr, Yongin 17074, South Korea; [Lee, Eun-Young; Yoon, Jisoo; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Hong, Ahreum] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174545
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/md18090463
- PubMed https://pubmed.ncbi.nlm.nih.gov/32927886
초록/요약
Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derivedStreptomycessp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-alpha), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.
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