Brain MRI Pattern Recognition in Neurodegeneration With Brain Iron Accumulation
- 주제(키워드) neurodegeneration , iron , NBIA , magnetic resonance imaging , pattern
- 주제(기타) Clinical Neurology
- 주제(기타) Neurosciences
- 설명문(일반) [Lee, Jae-Hyeok] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Neurol,Sch Med, Yangsan Si, South Korea; [Yun, Ji Young] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Neurol, Seoul, South Korea; [Gregory, Allison; Hogarth, Penelope; Hayflick, Susan J.] Oregon Hlth & Sci Univ, Dept Mol, Portland, OR 97201 USA; [Gregory, Allison; Hogarth, Penelope; Hayflick, Susan J.] Oregon Hlth & Sci Univ, Dept Med Genet, Portland, OR 97201 USA
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174555
- 본문언어 영어
- Published As http://dx.doi.org/10.3389/fneur.2020.01024
- PubMed https://pubmed.ncbi.nlm.nih.gov/33013674
초록/요약
Most neurodegeneration with brain iron accumulation (NBIA) disorders can be distinguished by identifying characteristic changes on magnetic resonance imaging (MRI) in combination with clinical findings. However, a significant number of patients with an NBIA disorder confirmed by genetic testing have MRI features that are atypical for their specific disease. The appearance of specific MRI patterns depends on the stage of the disease and the patient's age at evaluation. MRI interpretation can be challenging because of heterogeneously acquired MRI datasets, individual interpreter bias, and lack of quantitative data. Therefore, optimal acquisition and interpretation of MRI data are needed to better define MRI phenotypes in NBIA disorders. The stepwise approach outlined here may help to identify NBIA disorders and delineate the natural course of MRI-identified changes.
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