Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study
- 주제(기타) Gastroenterology & Hepatology
- 주제(기타) Surgery
- 설명문(일반) [Kim, Jae Ri; Jang, Jin-Young; Kim, Sun-Whe; Kwon, Wooil; Kim, Hongbeom] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Surg, Seoul, South Korea; [Lee, Kyungbun] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Pathol, Seoul, South Korea; [Kim, Jung Hoon] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea; [Choi, Dong Wook; Heo, JinSeok; Han, In Woong] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea; [Jang, Kee-Taek] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea; [Hwang, Shin; Kim, Wan-Joon] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Ulsan, South Korea; [Hong, Seung-Mo] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Ulsan, South Korea; [Kim, Dong-Sik; Yu, Young-Dong] Korea Univ, Coll Med, Dept Surg, Seoul, South Korea; [Kim, Joo Young] Korea Univ, Coll Med, Dept Pathol, Seoul, South Korea; [Nah, Yang Won; Park, Hyung Woo] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Surg, Ulsan, South Korea; [Choi, Hye-Jeong] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Pathol, Ulsan, South Korea; [Han, Ho-Seong; Yoon, Yoo-Seok] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Surg, Seoul, South Korea; [Kim, Haeryoung] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pathol, Seoul, South Korea; [Park, Sang Jae] Natl Canc Ctr, Dept Surg, Goyang Si, South Korea; [Hong, Eun Kyung] Natl Canc Ctr, Dept Pathol, Goyang Si, South Korea; [Seo, Hyung Il] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Surg, Busan, South Korea; [Park, Do Youn] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Pathol, Busan, South Korea; [Kang, Koo Jeong] Keimyung Univ, Sch Med, Dept Surg, Daegu, South Korea; [Kang, Yu Na] Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea; [Yu, Hee Chul] Chonbuk Natl Univ, Sch Med, Dept Surg, Jeonju, South Korea; [Moon, Woo Sung] Chonbuk Natl Univ, Sch Med, Dept Pathol, Jeonju, South Korea; [Lim, Chang-Sup] Seoul Natl Univ, Coll Med, Boramae Med Ctr, Dept Surg, Seoul, South Korea; [Bae, Jeong Mo] Seoul Natl Univ, Coll Med, Boramae Med Ctr, Dept Pathol, Seoul, South Korea; [Jo, Sungho] Dankook Univ, Coll Med, Dept Surg, Yongin, South Korea; [Lee, Wonae] Dankook Univ, Coll Med, Dept Pathol, Yongin, South Korea; [Roh, Young Hun] Dong A Univ, Coll Med, Dept Surg, Busan, South Korea; [Jeong, Jin Sook] Dong A Univ, Coll Med, Dept Pathol, Busan, South Korea; [Jeong, Chi-Young] Gyeongsang Natl Univ, Postgrad Sch Med, Dept Surg, Jinju, South Korea; [Lee, Jong Sil] Gyeongsang Natl Univ, Postgrad Sch Med, Dept Pathol, Jinju, South Korea; [Song, In-Sang] Chungnam Natl Univ, Sch Med, Dept Surg, Daejeon, South Korea; [Kim, Kyung-Hee] Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea; [Kim, Ho Gak] Daegu Catholic Univ, Sch Med, Dept Surg, Gyongsan, South Korea; [Cho, Chang Ho] Daegu Catholic Univ, Sch Med, Dept Pathol, Gyongsan, South Korea; [Joo, Sun-Hyung] Kyung Hee Univ, Sch Med, Dept Surg, Seoul, South Korea; [Won, Kyu Yeoun] Kyung Hee Univ, Sch Med, Dept Pathol, Seoul, South Korea; [Kim, Hong Jin] Yeungnam Univ, Coll Med, Dept Surg, Gyongsan, South Korea; [Choi, Joon Hyuk] Yeungnam Univ, Coll Med, Dept Pathol, Gyongsan, South Korea; [Chu, Chong-Woo] Pusan Natl Univ, Sch Med, Yangsan Hosp, Dept Surg, Busan, South Korea; [Lee, Jung Hee] Pusan Natl Univ, Sch Med, Yangsan Hosp, Dept Pathol, Busan, South Korea; [Park, Il Young] Catholic Univ, Coll Med, Dept Surg, Seoul, South Korea; [Lee, Heejeong] Catholic Univ, Coll Med, Dept Pathol, Seoul, South Korea; [Lee, Seung Eun] Chung Ang Univ, Coll Med, Dept Surg, Seoul, South Korea; [Kim, Hee Sung] Chung Ang Univ, Coll Med, Dept Pathol, Seoul, South Korea; [Lee, Hyeon Kook] Ewha Womans Univ, Sch Med, Dept Surg, Seoul, South Korea; [Cho, Min-Sun] Ewha Womans Univ, Sch Med, Dept Pathol, Seoul, South Korea; [Kim, Hongbeom] Dongguk Univ, Coll Med, Ilsan Hosp, Dept Surg, Seoul, South Korea; [Han, Kang Min] Dongguk Univ, Coll Med, Ilsan Hosp, Dept Pathol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Bronze
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174612
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.hpb.2019.11.007
- PubMed https://pubmed.ncbi.nlm.nih.gov/31837945
초록/요약
Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the "Jang & Kim's modified anatomical classification," 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010-4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.
more