Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells
- 주제(기타) Integrative & Complementary Medicine
- 설명문(일반) [Han, Ah-Reum; Kim, Jin-Baek] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup Si 56212, Jeollabuk Do, South Korea; [Lee, Sanghun] Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul 06110, South Korea; [Han, Sujin; Lee, Yeon Jin; Seo, Eun Kyoung] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Jung, Chan-Hun] Jeonju AgroBiomat Inst, Jeonju Si 54810, Jeollabuk Do, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 HINDAWI LTD
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174640
- 본문언어 영어
- Published As http://dx.doi.org/10.1155/2020/3683460
- PubMed https://pubmed.ncbi.nlm.nih.gov/33029164
초록/요약
Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3). These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations. These results suggest that triterpenoids 1-3 isolated from C.asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.
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