The role of sphingolipids in endoplasmic reticulum stress
- 주제(키워드) acyl chain length , ceramide , disease , endoplasmic reticulum stress , sphingolipid
- 등재 SCIE, SCOPUS
- OA유형 Bronze
- 발행기관 Wiley Blackwell
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174875
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/1873-3468.13863
- PubMed https://pubmed.ncbi.nlm.nih.gov/32538465
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The endoplasmic reticulum (ER) is an important intracellular compartment in eukaryotic cells and has diverse functions, including protein synthesis, protein folding, lipid metabolism and calcium homeostasis. ER functions are disrupted by various intracellular and extracellular stimuli that cause ER stress, including the inhibition of glycosylation, disulphide bond reduction, ER calcium store depletion, impaired protein transport to the Golgi, excessive ER protein synthesis, impairment of ER-associated protein degradation and mutated ER protein expression. Distinct ER stress signalling pathways, which are known as the unfolded protein response, are deployed to maintain ER homeostasis, and a failure to reverse ER stress triggers cell death. Sphingolipids are lipids that are structurally characterized by long-chain bases, including sphingosine or dihydrosphingosine (also known as sphinganine). Sphingolipids are bioactive molecules long known to regulate various cellular processes, including cell proliferation, migration, apoptosis and cell–cell interaction. Recent studies have uncovered that specific sphingolipids are involved in ER stress. This review summarizes the roles of sphingolipids in ER stress and human diseases in the context of pathogenic events. © 2020 Federation of European Biochemical Societies
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