Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer
- 주제(키워드) cancer , ECM remodeling , extracellular matrix , glycosaminoglycan , matrix metalloprotease , syndecan
- 등재 SCIE, SCOPUS
- OA유형 Bronze, Green Published
- 발행기관 SAGE Publications Ltd
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174877
- 본문언어 영어
- Published As http://dx.doi.org/10.1369/0022155420930112
- PubMed https://pubmed.ncbi.nlm.nih.gov/32623937
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor–mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions © The Author(s) 2020.
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