Diagnostic and therapeutic implications of micrornas in non-small cell lung cancer
- 주제(키워드) Diagnosis , MicroRNA , Non-small cell lung cancer , Prognosis
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI AG
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174915
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijms21228782
- PubMed https://pubmed.ncbi.nlm.nih.gov/33233641
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to progression and metastasis. They play roles in cell proliferation, apoptosis, angiogenesis, epithelial-to-mesenchymal transition, migration, invasion, and metastatic colonization, as well as immunosuppression. Due to their versatility, numerous attempts have been made to use miRNAs for clinical applications. miRNAs can be used as cancer subtype classifiers, diagnostic markers, drug-response predictors, prognostic markers, and therapeutic targets in NSCLC. Many challenges remain ahead of their actual clinical application; however, when achieved, the use of miRNAs in the clinic is expected to enable great progress in the diagnosis and treatment of patients with NSCLC. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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