Pharmacogenomic biomarkers and their applications in psychiatry
- 주제(키워드) Epilepsy , Personalized medicine , Pharmacogenomic biomarkers , Pharmacogenomics , Precision medicine , Psychiatric disorders , Psychiatry
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI AG
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000174925
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/genes11121445
- PubMed https://pubmed.ncbi.nlm.nih.gov/33266292
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims to summarize important issues on pharmacogenomics in psychiatry that have laid the foundation towards personalized pharmacotherapy and, in a broader sense, precision medicine. We present major pharmacogenomic biomarkers and their applications in a variety of psychiatric disorders, such as depression, attention-deficit/hyperactivity disorder (ADHD), narcolepsy, schizophrenia, and bipolar disorder. In addition, we extend the scope into epilepsy, since antiepileptic drugs are widely used to treat psychiatric disorders, although epilepsy is conventionally considered to be a neurological disorder. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
more