Plumbagin Suppresses Pulmonary Fibrosis Via Inhibition of p300 Histone Acetyltransferase Activity
- 주제(키워드) histone acetyltransferase , p300 , plumbagin , pulmonary fibrosis
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Food Science & Technology
- 주제(기타) Nutrition & Dietetics
- 설명문(일반) [Lee, Soo Yeon; Kim, Mi Jeong; Jang, Subhin; Lee, Gyeong-Eun; Park, Soo-Yeon; Yoon, Ho-Geun] Yonsei Univ, Severance Med Res Inst, Dept Biochem & Mol Biol, Coll Med,Brain Korea 21 Plus Project Med Sci, Seoul 03722, South Korea; [Hwang, Soo-Yeon; Kwon, Youngjoo] Ewha Womans Univ, Coll Pharm, Seoul, South Korea; [Hwang, Soo-Yeon; Kwon, Youngjoo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Hong, Jung Yeon; Sohn, Myung Hyun] Yonsei Univ, Severance Med Res Inst, Dept Pediat, Coll Med,Brain Korea 21 Plus Project Med Sci, Seoul, South Korea; [Hong, Jung Yeon; Sohn, Myung Hyun] Yonsei Univ, Severance Med Res Inst, Inst Allergy, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 MARY ANN LIEBERT, INC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174959
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/jmf.2019.4670
- PubMed https://pubmed.ncbi.nlm.nih.gov/32311286
초록/요약
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-beta-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.
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