Glycosaminoglycan-Induced Emissive J-Aggregate Formation in a meso-Ester BODIPY Dye
- 주제(키워드) aggregation-induced emission (AIE) , BODIPY , fluorescent probes , heparin , J-aggregates
- 주제(기타) Materials Science, Multidisciplinary
- 주제(기타) Optics
- 설명문(일반) [Kim, Dami; Lee, Uisung; Kim, Youngmi] Kyung Hee Univ, Dept Chem, 26 Kyungheedae Ro, Seoul 02447, South Korea; [Bouffard, Jean] Ewha Womans Univ, Dept Chem & Nanosci, BK 21 Plus, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000174965
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/adom.201902161
초록/요약
The analyte-directed formation of emissive J-aggregates of a meso-ester BODIPY dye is explored in the design of fluorescence "light-up" probes. The heparin-specific pyridinium-functionalized meso-ester BODIPY dye C10-Py+ self-assembles in aqueous buffer into spherical aggregated nanostructures with spectroscopic features indistinguishable from the monomeric dye (signal off). In the presence of heparin, the aggregated assemblies rearrange and associate with heparin through charge-pairing interactions, triggering the spontaneous formation of emissive J-type aggregates (signal on). The heparin-induced J-aggregate formation of C10-Py+ provides an excellent "turn-on" signal with large spectral shifts. The response is highly selective for heparin over other closely related glycosaminoglycan (GAG) analogues, sensitive, fast, and operationally simple. Assays for heparin in human serum, and for the adulterant OSCS in heparin are demonstrated, confirming the reliability and robustness of the J-aggregation approach using meso-ester BODIPY dyes in the design of aggregation-induced emission (AIE)-based fluorogenic probes.
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