Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis
- 주제(키워드) Air movements , Atopic dermatitis , Environmental impact , Filaggrin , Wind
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 Japanese Society of Allergology
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175001
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.alit.2019.11.004
- PubMed https://pubmed.ncbi.nlm.nih.gov/31883634
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. Results: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). Conclusions: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner. © 2019 Japanese Society of Allergology
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