Regulation of deubiquitinating enzymes by post-translational modifications
- 주제(키워드) Activity , Deubiquitinase (DUB) , Deubiquitinating enzyme , Disease , Interaction , Localization , Post-translational modification (PTM)
- 등재 SCIE, SCOPUS
- OA유형 Green Published
- 발행기관 MDPI AG
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175015
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijms21114028
- PubMed https://pubmed.ncbi.nlm.nih.gov/32512887
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes, and the enzymes involved are tightly regulated by multiple factors including posttranslational modifications like most other proteins. Dysfunction or misregulation of these enzymes could have dramatic physiological consequences, sometimes leading to diseases. Therefore, it is important to have a clear understanding of these regulatory processes. Here, we have reviewed the posttranslational modifications of deubiquitinating enzymes and their consequences on the catalytic activity, stability, abundance, localization, and interaction with the partner proteins. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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