Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice
- 주제(키워드) Aging , Brain endothelial cell , Estrogen , Hepcidin , Iron accumulation , Postmenopause
- 주제(기타) Geriatrics & Gerontology
- 주제(기타) Neurosciences
- 설명문(일반) [Shin, Jin A.; Park, Eun-Mi] Ewha Womans Univ, Coll Med, Dept Pharmacol, 25 Magokdong Ro 2 Gil, Seoul 07084, South Korea; [Kim, Hee-Sun] Ewha Womans Univ, Coll Med, Dept Mol Med, Seoul, South Korea; [Kang, Jihee Lee] Ewha Womans Univ, Coll Med, Dept Physiol & Inflammat, Canc Microenvironm Res Ctr, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175081
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.neurobiolaging.2020.08.010
- PubMed https://pubmed.ncbi.nlm.nih.gov/32920472
초록/요약
The total iron level in the brain increases with age, and excess iron is associated with neurodegenerative diseases; however, the mechanism of brain iron deposition is unknown. In peripheral cells, the expression of hepcidin, a master regulator of iron homeostasis, is regulated by estrogen. This study aimed to determine whether hepcidin was involved in iron deposition in the brain and brain endothelial cells of estrogen-deficient aged female mice. Aged mice showed increased levels of hepcidin and ferritin in the brain and brain microvessels compared with young mice, and these levels were reduced by estrogen replacement in ovariectomized aged mice. In the brain endothelial cell line bEnd.3, the lipopolysaccharide (10 ng/mL)-induced increases of hepcidin mRNA and protein levels, the number of Prussian blue-positive cells, and free radicals were reduced after estrogen treatment. These results suggest that estrogen deficiency with an increase of hepcidin is partly responsible for iron deposition in the brain and brain endothelial cells and that hepcidin can be a target to prevent brain aging and neurodegeneration in postmenopausal women. (C) 2020 Elsevier Inc. All rights reserved.
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