Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells
- 주제(기타) Plant Sciences
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Lee, Jihye] REDONE Seoul, Labs Marine New Drugs, Seoul 08594, South Korea; [Lee, Jihye; Hillman, Prima F.; Lee, Eun Young; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Gamage, Chathurika D. B.; Kim, Hangun] Sunchon Natl Univ, Coll Pharm, Jeonnam 57922, South Korea; [Kim, Geum Jin; Choi, Hyukjae] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea; [Kim, Geum Jin; Choi, Hyukjae] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38531, Gyeongsangbukdo, South Korea; [Lee, Chaeyoung] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Fenical, William] Univ Calif San Diego, Ctr Marine Biotechnol & Biomed, Scripps Inst Oceanog, La Jolla, CA 92093 USA
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175118
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.jnatprod.0c00815
- PubMed https://pubmed.ncbi.nlm.nih.gov/32985880
초록/요약
A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.
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