Effect of PTH and corticotomy on implant movement under mechanical force
- 주제(키워드) Implant , Bone remodeling , Parathyroid hormone , Corticotomy , Orthodontic force
- 주제(기타) Dentistry, Oral Surgery & Medicine
- 설명문(일반) [Kim, Jiyeon] Ewha Womans Univ, Sch Med, Seoul, South Korea; [Kim, Heon-Young; Kim, Jin-Woo] Ewha Womans Univ, Sch Med, Dept Oral & Maxillofacial Surg, Seoul 158710, South Korea; [Kim, Won-Ho; Kim, Min-Ji] Ewha Womans Univ, Sch Med, Dept Orthodont, Anyangcheon Ro 1071, Seoul 158710, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 BMC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175133
- 본문언어 영어
- Published As http://dx.doi.org/10.1186/s12903-020-01310-4
- PubMed https://pubmed.ncbi.nlm.nih.gov/33172437
초록/요약
Background Osseointegrated implants are considered as clinically non-movable. Parathyroid hormone (PTH) is known to play a significant role in the regulation of bone remodeling and in intermittent, low doses, result in osteoanabolic effects. This study aimed to investigate the effects of PTH and corticotomy, both under traction force, on osseointegrated implants. Methods Four implants-two in each hemimandible-were placed in each of the three study mongrels. Each mongrels were designated as control, normal dose PTH (PTH-1), and high dose PTH (PTH-2) groups, with each groups further subdivided into non-surgery implant and surgery implant. After osseointegration, mechanical force with NiTi closed coil springs (500 g) was applied around each implants. Corticotomy was performed around one of four implants in each mongrels. Parathyroid hormone was administered locally on a weekly basis for 20 weeks. Clinical movement of the implants were evaluated with the superimposed 3D- scanned data, bone- microarchitectural and histologic examinations. Results Superimposition analysis showed continuous movement of the non-surgery implant of PTH-1 group. Movement was further justified with lowest bone implant contact (adjusted BIC; 44.77%) in histomorphometric analysis. Upregulation of bone remodeling around the implant was observed in the normal dose PTH group. In the surgery implants, the remarkably higher adjusted BIC compared to the non-surgery implants indicated increased bone formation around the implant surface. Conclusion The results indicate that the catabolic and anabolic balance of osseointegrated implants in terms of bone remodeling can be shifted via various interventions including pharmacological, surgical and mechanical force.
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