Gut microbiota and metabolic health among overweight and obese individuals
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Kim, Mi-Hyun; Yun, Kyung Eun; Kim, Jimin; Chang, Yoosoo; Ryu, Seungho; Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea; [Park, Eunkyo; Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea; [Chang, Yoosoo; Ryu, Seungho; Kim, Han-Na] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul 03181, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 NATURE RESEARCH
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175134
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-020-76474-8
- PubMed https://pubmed.ncbi.nlm.nih.gov/33173145
초록/요약
Although obesity is associated with numerous diseases, the risks of disease may depend on metabolic health. Associations between the gut microbiota, obesity, and metabolic syndrome have been reported, but differences in microbiomes according to metabolic health in the obese population have not been explored in previous studies. Here, we investigated the composition of gut microbiota according to metabolic health status in obese and overweight subjects. A total of 747 overweight or obese adults were categorized by metabolic health status, and their fecal microbiota were profiled using 16S ribosomal RNA gene sequencing. We classified these adults into a metabolically healthy group (MH, N=317) without any components of metabolic syndrome or a metabolically unhealthy group (MU, N=430) defined as having at least one metabolic abnormality. The phylogenetic and non-phylogenetic alpha diversity for gut microbiota were lower in the MU group than the MH group, and there were significant differences in gut microbiota bacterial composition between the two groups. We found that the genus Oscillospira and the family Coriobacteriaceae were associated with good metabolic health in the overweight and obese populations. This is the first report to describe gut microbial diversity and composition in metabolically healthy and unhealthy overweight and obese individuals. Modulation of the gut microbiome may help prevent metabolic abnormalities in the obese population.
more