The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
- 주제(키워드) Alcohol , Alcoholic fatty liver disease , Hepatic steatosis , Peroxiredoxin III , PTEN , Reactive oxygen species
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Inc.
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175349
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.022
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPARγ. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD. © 2020
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