Fumonisin b1-induced toxicity was not exacerbated in glutathione peroxidase-1/catalase double knock out mice
- 주제(키워드) Catalase , Fumonisin B1 , Glutathione peroxidase1 , Sphinganine , Sphingosine
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 Korean Society of Applied Pharmacology
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175382
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2020.062
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregula-tion. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotrans-ferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice. © 2021 The Korean Society of Applied Pharmacology.
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