Antaroide, a novel natural nine-membered macrolide, inhibits melanin biosynthesis in b16f10 murine melanoma cells
- 주제(키워드) Marine natural product , Melanin synthesis inhibitor , Nine-membered macrolide , Skin whitening agent , Streptomyces sp
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 Korean Society of Applied Pharmacology
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175586
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2020.064
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Inten-sive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents. © 2021 The Korean Society of Applied Pharmacology.
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