Napthalimide-based fluorescent probe for selective and sensitive sensing of formaldehyde and biological applications
- 주제(키워드) Condensation reaction , Formaldehyde sensing , Luminescent detection , Napthalimide , Two-photon excitation
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175689
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dyepig.2021.109156
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Formaldehyde (FA) is a colorless, flammable, foul-smelling chemical used in building materials and in the production of numerous household chemical products. To develop a fluorescent chemosensor for FA, a newly prepared probe 1 containing napthalimide as a fluorophore and hydrazine as a binding site of FA was designed and prepared. The amine group of the hydrazine reacts with FA to form an imide bond. Indeed, the absorption band of probe 1 at 438 nm shifted to 443 nm upon the addition of FA, indicating that the condensation reaction occurred. Also, the addition of FA to probe 1 induced a large enhancement of the emission band at 532 nm compared with the relatively very weak fluorescent emission of probe 1 alone. This high specificity toward FA was observed over other competing analytes such as Ca2+, Mg2+, acetaldehyde, benzaldehyde, salicylaldehyde, glucose, glutathione, Na2S, NaHS, H2O2, and tert-butylhydroperoxy radical. The typical two-photon dye present in probe 1 also afforded intense fluorescence upon excitation, even at 800 nm, demonstrating that probe 1 could be used for a two-photon fluorescent probe for FA sensing. Probe 1 had a quick response time in the sensing of FA at room temperature. In addition, breast cancer cells treated with probe 1 exhibited intense fluorescence imaging upon exposure to FA, indicating that probe 1 could be used for monitoring FA in living cells. This probe can lead to new possibilities for unique interactions with biological molecules for applications. © 2021
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