Large-scale association analyses identify host factors influencing human gut microbiome composition
- 등재 SCIE, SCOPUS
- OA유형 Green Published, Green Submitted, Green Accepted
- 발행기관 Nature Research
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175690
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41588-020-00763-1
- PubMed https://pubmed.ncbi.nlm.nih.gov/33462485
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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