The impact of remission and coexisting migraine on anxiety and depression in cluster headache
- 주제(키워드) Anxiety , Cluster headache , Depression , Headache , Migraine
- 주제(기타) Clinical Neurology
- 주제(기타) Neurosciences
- 설명문(일반) [Kim, Byung-Su] Bundang Jesaeng Gen Hosp, Daejin Med Ctr, Dept Neurol, Seongnam, South Korea; [Chung, Pil-Wook; Moon, Heui-Soo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Neurol, Sch Med, Seoul, South Korea; [Kim, Byung-Kun] Eulji Univ, Eulji Hosp, Dept Neurol, Seoul, South Korea; [Lee, Mi Ji; Chung, Chin-Sang] Sungkyunkwan Univ, Neurosci Ctr, Samsung Med Ctr, Dept Neurol,Sch Med, Seoul, South Korea; [Park, Jeong Wook] Catholic Univ Korea, Dept Neurol, Uijeongbu St Marys Hosp, Coll Med, Uijongbu, South Korea; [Chu, Min Kyung] Yonsei Univ, Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea; [Ahn, Jin-Young] Seoul Med Ctr, Dept Neurol, Seoul, South Korea; [Bae, Dae Woong] Catholic Univ Korea, Coll Med, Dept Neurol, Suwon, South Korea; [Song, Tae-Jin] Ewha Womans Univ, Coll Med, Dept Neurol, Seoul Hosp, Seoul, South Korea; [Sohn, Jong-Hee] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Neurol, Chunchon, South Korea; [Oh, Kyungmi] Korea Univ, Dept Neurol, Coll Med, Seoul, South Korea; [Kim, Daeyoung; Kim, Jae-Moon] Chungnam Natl Univ, Dept Neurol, Coll Med, Daejeon, South Korea; [Kim, Soo-Kyoung] Gyeongsang Natl Univ, Dept Neurol, Coll Med, Jinju, South Korea; [Choi, Yun-Ju] Dr Chois Neurol Clin, Jeonju, South Korea; [Chung, Jae Myun] Inje Univ, Dept Neurol, Coll Med, Seoul, South Korea; [Park, Kwang-Yeol] Chung Ang Univ Hosp, Dept Neurol, 102 Heukseok Ro, Seoul 06973, South Korea; [Cho, Soo-Jin] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Neurol, Coll Med, Keun Jae Bong Gil 7, Hwaseong 18450, Gyeonggi Do, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 BMC
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175743
- 본문언어 영어
- Published As http://dx.doi.org/10.1186/s10194-020-01120-7
- PubMed https://pubmed.ncbi.nlm.nih.gov/32471362
초록/요약
Background Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. Methods We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of >= 10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods. Results Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35-15.99 and aOR = 4.95, 95% CI = 2.32-10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63-159.64 and aOR = 16.88, 95% CI = 4.16-68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 +/- 5.6 to 1.6 +/- 2.8; P < 0.001, and from 6.1 +/- 5.0 to 1.8 +/- 2.4; P < 0.001, respectively). Conclusions Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.
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