Butler enables rapid cloud-based analysis of thousands of human genomes
- 주제(기타) Biotechnology & Applied Microbiology
- 설명문(일반) [Yakneen, Sergei; Waszak, Sebastian M.; Korbel, Jan O.; Weischenfeldt, Joachim] European Mol Biol Lab, Genome Biol Unit, Heidelberg, Germany; [Yakneen, Sergei; Gertz, Michael] Heidelberg Univ, Inst Comp Sci, Heidelberg, Germany; [Korbel, Jan O.; Boyce, Rich; Cafferkey, Andy; Flicek, Paul; Fonseca, Nuno A.; Newhouse, Steven J.; Ocana, David; Short, Charles] European Bioinformat Inst, EMBL, Hinxton, England; [Yakneen, Sergei] Sophia Genet SA, St Sulpice, Switzerland; [Aminou, Brice; Byrne, Niall J.; Fayzullaev, Nodirjon; Ferretti, Vincent; Gibson, Bob; Mihaiescu, George L.; Nahal-Bose, Hardeep K.; O'Connor, Brian D.; Perry, Marc D.; Yung, Christina K.; Zhang, Junjun] Ontario Inst Canc Res, Genome Informat Program, Toronto, ON, Canada; [Bartolome, Javier; Gelpi, Josep Ll; Puiggros, Montserrat; Royo, Romina; Torrents, David; Vicente, David] Barcelona Supercomp Ctr, Barcelona, Spain; [Boroevich, Keith A.] RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Yokohama, Kanagawa, Japan; [Boroevich, Keith A.; Nakagawa, Hidewaki] RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan; [Brooks, Angela N.; Getz, Gad; Hess, Julian M.; Leshchiner, Ignaty; Livitz, Dimitri; Rheinbay, Esther; Rosenberg, Mara; Saksena, Gordon; Tiao, Grace; Wala, Jeremiah A.] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; [Brooks, Angela N.; Wala, Jeremiah A.] Dana Farber Canc Inst, Boston, MA 02115 USA; [Brooks, Angela N.; O'Connor, Brian D.] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA; [Buchanan, Alex; Ellrott, Kyle; Struck, Adam J.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA; [Buchhalter, Ivo; Eils, Roland; Heinold, Michael C.; Kabbe, Rolf; Kerssemakers, Jules N. A.; Kleinheinz, Kortine; Paramasivam, Nagarajan; Prinz, Manuel; Schlesner, Matthias; Werner, Johannes] German Canc Res Ctr, Div Theoret Bioinformat, Heidelberg, Germany; [Buchhalter, Ivo] German Canc Res Ctr, Heidelberg Ctr Personalized Oncol DKFZ HIPO, Heidelberg, Germany; [Buchhalter, Ivo; Eils, Roland; Heinold, Michael C.; Huebschmann, Daniel; Kleinheinz, Kortine] Heidelberg Univ, Inst Pharm & Mol Biotechnol, Heidelberg, Germany; [Buchhalter, Ivo; Eils, Roland; Heinold, Michael C.; Huebschmann, Daniel; Kleinheinz, Kortine] Heidelberg Univ, BioQuant, Heidelberg, Germany; [Butler, Adam P.; Campbell, Peter J.; Clapham, Peter; Nicholson, Jonathan; Raine, Keiran M.] Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge, England; [Campbell, Peter J.] Univ Cambridge, Dept Haematol, Cambridge, England; [Chen, Zhaohong; Dow, Michelle T.; Farcas, Claudiu; Koures, Antonios; Ohno-Machado, Lucila; Williams, Ashley] Univ Calif San Diego, San Diego, CA 92103 USA; [Cho, Sunghoon] PDXen Biosyst Inc, Seoul, South Korea; [Choi, Wan; Jeon, Seung-Hyup; Kim, Hyunghwan; Woo, Youngchoon] Elect & Telecommun Res Inst, Daejeon, South Korea; [Davis-Dusenbery, Brandi N.] Seven Bridges Genom, Charlestown, MA USA; [De La Vega, Francisco M.] Annai Syst Inc, Carlsbad, CA USA; [De La Vega, Francisco M.] Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA 94305 USA; [De La Vega, Francisco M.] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA; [De La Vega, Francisco M.] Stanford Univ, Dept Genet & Biomed Data Sci, Sch Med, Stanford, CA 94305 USA; [Demeulemeester, Jonas; Van Loo, Peter] Univ Leuven, Leuven, Belgium; [Demeulemeester, Jonas; Van Loo, Peter] Francis Crick Inst, London, England; [Dursi, Lewis Jonathan; Jiao, Wei; Shorser, Solomon, I; Stein, Lincoln D.; Wright, Adam J.; Yuen, Denis] Ontario Inst Canc Res, Computat Biol Program, Toronto, ON, Canada; [Dursi, Lewis Jonathan] Hosp Sick Children, Toronto, ON, Canada; [Eils, Juergen; Eils, Roland; Huebschmann, Daniel] Heidelberg Univ, Heidelberg, Germany; [Eils, Juergen; Eils, Roland; Lawerenz, Chris] Berlin Inst Hlth, New BIH Digital Hlth Ctr, Berlin, Germany; [Eils, Juergen; Eils, Roland; Lawerenz, Chris] Charite Univ Med Berlin, Berlin, Germany; [Favero, Francesco] Rigshosp, Copenhagen, Denmark; [Ferretti, Vincent] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada; [Fonseca, Nuno A.] Univ Porto, CIBIO InBIO Res Ctr Biodivers & Genet Resources, Vairo, Portugal; [Gelpi, Josep Ll] Univ Barcelona, Dept Biochem & Mol Biomed, Barcelona, Spain; [Getz, Gad] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA; [Getz, Gad] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA; [Getz, Gad; Rheinbay, Esther; Wala, Jeremiah A.] Harvard Med Sch, Boston, MA 02115 USA; [Grossman, Robert L.; Spring, Jonathan] Univ Chicago, Chicago, IL 60637 USA; [Harismendy, Olivier] UC San Diego Sch Med, Dept Med, Div Biomed Informat, San Diego, CA USA; [Harismendy, Olivier] UC San Diego Sch Med, Moores Canc Ctr, San Diego, CA USA; [Heath, Allison P.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA; [Hess, Julian M.] Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA USA; [Hofmann, Oliver] Univ Melbourne, Ctr Canc Res, Melbourne, Vic, Australia; [Hong, Jongwhi H.] Syntekabio Inc, Daejeon, South Korea; [Hudson, Thomas J.] AbbVie, N Chicago, IL USA; [Hudson, Thomas J.] Ontario Inst Canc Res, Genom Program, Toronto, ON, Canada; [Hutter, Barbara] German Canc Consortium DKTK, Heidelberg, Germany; [Hutter, Barbara; Paramasivam, Nagarajan] German Canc Res Ctr, Heidelberg Ctr Personalized Oncol DKFZ HIPO, Heidelberg, Germany; [Hutter, Barbara] Natl Ctr Tumor Dis NCT Heidelberg, Heidelberg, Germany; [Hutter, Carolyn M.; Sofia, Heidi J.] NHGRI, NIH, Bethesda, MD 20892 USA; [Huebschmann, Daniel] Univ Hosp, Dept Pediat Immunol Hematol & Oncol, Heidelberg, Germany; [Huebschmann, Daniel] German Canc Res Ctr, Heidelberg, Germany; [Huebschmann, Daniel] Heidelberg Inst Stem Cell Technol & Expt Med HI S, Heidelberg, Germany; [Imoto, Seiya; Miyano, Satoru; Miyoshi, Naoki; Ohi, Kazuhiro] Univ Tokyo, Inst Med Sci, Tokyo, Japan; [Ivkovic, Sinisa; Mijalkovic, Sanja; Lazic, Ana Mijalkovic; Nastic, Mia; Radovic, Petar; Tijanic, Nebojsa] Seven Bridges, Charlestown, MA USA; [Jung, Jongsun; Kovacevic, Milena] Syntekabio Inc, Genome Integrat Data Ctr, Daejeon, South Korea; [Kahles, Andre; Raetsch, Gunnar] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, 1275 York Ave, New York, NY 10021 USA; [Kahles, Andre; Raetsch, Gunnar] Swiss Fed Inst Technol, Dept Biol, Zurich, Switzerland; [Kahles, Andre; Raetsch, Gunnar] Swiss Fed Inst Technol, Dept Comp Sci, Zurich, Switzerland; [Kahles, Andre; Raetsch, Gunnar] SIB, Lausanne, Switzerland; [Kahles, Andre; Raetsch, Gunnar] Univ Hosp Zurich, Zurich, Switzerland; [Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul, South Korea; [Kim, Jihoon] Univ Calif San Diego, Hlth Sci Dept Biomed Informat, La Jolla, CA 92093 USA; [Kim, Youngwook] Sungkyunkwan Univ, Dept Hlth Sci & Technol, Sch Med, Seoul, South Korea; [Kim, Youngwook] Samsung Genome Inst, Seoul, South Korea; [Koscher, Michael] German Canc Res Ctr, Funct & Struct Genom, Heidelberg, Germany; [Liu, Jia] Leidos Biomed Res Inc, Mclean, VA USA; [Omberg, Larsson] Sage Bionetworks, Seattle, WA USA; [Ouellette, B. F. Francis] Ontario Inst Canc Res, Genome Informat, Toronto, ON, Canada; [Ouellette, B. F. Francis] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada; [Perry, Marc D.] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA; [Pihl, Todd D.] CSRA Inc, Fairfax, VA USA; [Rheinbay, Esther; Rosenberg, Mara; Vazquez, Miguel] Massachusetts Gen Hosp, Boston, MA 02114 USA; [Raetsch, Gunnar] Weill Cornell Med Coll, New York, NY USA; [Schlesner, Matthias] German Canc Res Ctr, Bioinformat & Omics Data Analyt, Heidelberg, Germany; [Stein, Lincoln D.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada; [Torrents, David; Vazquez, Miguel] ICREA, Barcelona, Spain; [Wang, Zhining; Yang, Liming] NCI, NIH, Bethesda, MD 20892 USA; [Weischenfeldt, Joachim] Univ Copenhagen, Finsen Lab, Copenhagen, Denmark; [Weischenfeldt, Joachim] Univ Copenhagen, BRIC, Copenhagen, Denmark; [Weischenfeldt, Joachim] Charite Univ Med Berlin, Dept Urol, Berlin, Germany; [Werner, Johannes] Leibniz Inst Baltic Sea Res, Dept Biol Oceanog, Rostock, Germany; [Xiang, Qian] Ontario Inst Canc Res, Toronto, ON, Canada
- 등재 SCIE, SCOPUS
- OA유형 Green Published, Green Submitted, Green Accepted
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175756
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41587-019-0360-3
- PubMed https://pubmed.ncbi.nlm.nih.gov/32024987
초록/요약
Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities. We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
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