The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer
- 주제(키워드) cervical cancer , prognosis , complete blood count , statistical model
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Noh, Joseph J.; Choi, Chel Hun] Sungkyunkwan Univ, Div Gynecol Oncol, Dept Obstet & Gynecol, Samsung Med Ctr,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; [Lim, Myong Cheol] Natl Canc Ctr, Div Tumor Immunol, Ctr Gynecol Ctr, Grad Sch Canc Sci & Policy, Goyang 10408, South Korea; [Lim, Myong Cheol] Natl Canc Ctr, Ctr Clin Trials, Res Inst & Hosp & Canc Control & Policy, Goyang 10408, South Korea; [Kim, Moon-Hong] Korea Canc Ctr Hosp, Dept Obstet & Gynecol, Korea Inst Radiol & Med Sci, Seoul 01812, South Korea; [Kim, Yun Hwan] Univ Ulsan, Dept Obstet & Gynecol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; [Song, Eun Seop] Gwangjin Gu Hlth Ctr, Med Treatment Div, Seoul 05026, South Korea; [Seong, Seok Ju] CHA Univ, Dept Obstet & Gynecol, CHA Gangnam Med Ctr, Seoul 06135, South Korea; [Suh, Dong Hoon] Seoul Natl Univ, Dept Obstet & Gynecol, Bundang Hosp, Seongnam 13620, South Korea; [Lee, Jong-Min] Kyung Hee Univ, Dept Obstet & Gynecol, Kyung Hee Univ Hosp Gangdong, Sch Med, Seoul 05278, South Korea; [Lee, Chulmin] CHA Univ, Dept Obstet & Gynecol, CHA Ilsan Med Ctr, Seoul 10414, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000175776
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm9092960
초록/요약
The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patients from nine tertiary medical centers in South Korea who were treated surgically for early stage cervical cancer were reviewed. Statistical models by the Akaike's information criterion (AIC) were developed using CBC profiles to calculate individuals' risk scores for clinical outcomes. A total of 1443 patients were included in the study and the median follow-up was 63.7 months with a range of 3-183 months. Univariate analyses identified the components of CBC that were significantly related to clinical outcomes including white blood cell (WBC), hemoglobin, neutrophil, and platelet levels. The models developed using CBC profiles and the conventional clinical predictive factors provided individuals' risk scores that were significantly better in predicting clinical outcomes than the models using the conventional clinical predictive factors alone. Pre-treatment CBC profiles including WBC, hemoglobin, neutrophil, lymphocyte, and platelet levels were found to be a potential biomarker for survival prognosis in early cervical cancer.
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