Adenovirus Vectors: Excellent Tools for Vaccine Development
- 주제(키워드) Adenovirus , Genetic vector , Adenovector , Vaccine
- 주제(기타) 기타면역학
- 설명문(URI) https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002692714
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 대한면역학회
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000179928
- 본문언어 영어
- Published As http://dx.doi.org/10.4110/in.2021.21.e6
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.
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