A Case of Atypical Central Skull Base Osteomyelitis with Bilateral Alveolar Bone Destruction
- 주제(키워드) Skull base , Osteomyelitis , Mucormycosis , Maxilla , Alveolar process
- 주제(기타) 이비인후과학
- 설명문(URI) https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002695855
- 등재 KCI등재
- 발행기관 대한비과학회
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000180173
- 본문언어 영어
- Published As http://dx.doi.org/10.18787/jr.2020.00337
초록/요약
Central skull base osteomyelitis (CSBO) is a rare, fatal condition seen mostly in elderly diabetic or immunocompromised patients; it mainly involves the sphenoid or occipital bones and diagnosis is often delayed. A 72-year-old male with diabetes was referred to our department with severe pain in the maxillary gingiva. Endoscopic biopsy of the pterygoid bone confirmed the presence of mucormycosis combined with Klebsiella pneumoniae infection. Sinus surgery was performed with bilateral alveolar bone sequestrectomy. Long-term intravenous broad-spectrum antibiotic therapy using meropenem and ampicillin/sulbactam and antifungal therapy using amphotericin B (100 mg/day) was administered; an oral antifungal agent, posaconazole (800 mg/day), was also prescribed for 11 weeks. At the 6-month follow-up visit, there were no complications and no progression of the CSBO lesion was observed. Timely diagnosis and multidisciplinary treatment including endoscopic surgery, alveolar bone sequestrectomy, and combined antifungal and antibiotic therapy can reduce mortality and minimize complications associated with CSBO
more