Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Qiao, Bin; Liang, Xing-Jie] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Qiao, Bin; Cao, Jin; Luo, Yuanli; Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Li, Hao; Lee, Jin Yong] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea; [Swamy, Kunemadihalli Mathada Kotraiah; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea; [Swamy, Kunemadihalli Mathada Kotraiah] VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584103, Karnataka, India; [Cheng, Hong-Bo; Zhao, Jing] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing Lab Biomed Mat, State Key Lab Organ Inorgan Composites,Coll Mat S, Beijing 100029, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181394
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/jacs.0c12851
초록/요약
The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (O-1(2)) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the O-1(2) generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.
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