Activatable supramolecular photosensitizers: advanced design strategies
- 주제(기타) Chemistry, Multidisciplinary
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Yang, Mengyao; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Li, Xingshu] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181409
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/d0qm00827c
초록/요약
Activatable photosensitizers (aPSs) are a new, switchable smart photosensitizer (PS) that can enhance photodynamic therapy (PDT) specificity and efficiency. aPSs are inert in healthy tissues, but can be switched on by neoplastic-associated endogenous stimuli such as pH, enzymes, and glutathione (GSH) and reduce damage to normal cells. This review summarizes aPS-based design strategies based on energy or electron transfer and self-quenching. We supplement the advanced design strategies with newly-developed molecular aPSs and focus on introducing nano-engineering supramolecular aPS construction.
more