Empirical assessment of biases in cerebrospinal fluid biomarkers of Alzheimer's disease: an umbrella review and re-analysis of data from meta-analyses
- 주제(키워드) Alzheimer's disease , CSF biomarkers , Meta-analysis , Umbrella review , Excess significance
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Jeong, D. Y.; Kim, J. Y.; Yoon, S.; Hong, S. H.] Yonsei Univ, Coll Med, Seoul, South Korea; [Lee, J.] Yonsei Univ, Dept Psychiat, Wonju Coll Med, Wonju, South Korea; [Lee, K. H.; Shin, J., I] Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea; [Li, H.] Univ Florida, Coll Med, Gainesville, FL USA; [Lee, J. Y.] Yonsei Univ, Dept Nephrol, Wonju Coll Med, Wonju, South Korea; [Jeong, G. H.] Gyeongsang Natl Univ, Coll Med, Jinju, South Korea; [Park, E. L.] Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; [Hong, S. H.] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA; [Kang, J. W.] Chungnam Natl Univ, Dept Pediat, Coll Med, Daejon, South Korea; [Song, T-J] Ewha Womans Univ, Dept Neurol, Seoul Hosp, Coll Med, Seoul, South Korea; [Leyhe, T.] Univ Basel, Geriatr Psychiat, Univ Dept Geriatr Med FELIX PLATTER, Basel, Switzerland; [Leyhe, T.] Psychiat Univ Hosp, Ctr Old Age Psychiat, Basel, Switzerland; [Eisenhut, M.] Luton & Dunstable Univ Hosp NHS Fdn Trust, Dept Pediat, Luton, Beds, England; [Kronbichler, A.] Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, Innsbruck, Austria; [Smith, L.] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England; [Solmi, M.; Fusar-Poli, P.] Univ Padua, Padova Neurosci Ctr PNC, Dept Neurosci, Padua, Italy; [Solmi, M.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect Epic Lab, London, England; [Stubbs, B.] Kings Coll London, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London, England; [Stubbs, B.] South London & Maudsley NHS Fdn Trust, Denmark Hill, London, England; [Stubbs, B.] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, Essex, England; [Koyanagi, A.; Jacob, L.] Univ Barcelona, Fundacio St Joan de Deu, CIBERSAM, Parc Sanitari St Joan de Deu, Barcelona, Spain; [Koyanagi, A.] ICREA, Pg Lluis Co 23, Barcelona, Spain; [Jacob, L.] Univ Versailles St Quentin En Yvelines, Fac Med, Montigny Le Bretonneux, France; [Stickley, A.] Sodertorn Univ, Stockholm Ctr Hlth & Social Change SCOHOST, Huddinge, Sweden; [Thompson, T.] Univ Greenwich, Dept Psychol, London, England; [Dragioti, E.] Linkoping Univ, Pain & Rehabil Ctr, Linkoping, Sweden; [Dragioti, E.] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden; [Oh, H.] Univ Southern Calif, Sch Social Work, Los Angeles, CA 90007 USA; [Brunoni, A. R.] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany; [Brunoni, A. R.] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Dept Psychiat, Lab Neurosci LIM 27,Inst Psychiat, Sao Paulo, Brazil; [Brunoni, A. R.] Univ Sao Paulo, Natl Inst Biomarkers Neuropsychiat INBioN, Inst Psychiat, Sao Paulo, Brazil; [Brunoni, A. R.] Univ Sao Paulo, Fac Med, Dept Clin Med, Hosp Univ, Sao Paulo, Brazil; [Carvalho, A. F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada; [Carvalho, A. F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada; [Kim, M. S.] Korea Univ, Coll Med, Seoul, South Korea; [Kim, M. S.] Minist Hlth & Welf, Cheongsan Publ Hlth Ctr, Wando, South Korea; [Yon, D. K.] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Pediat, Coll Med, Seoul, South Korea; [Lee, S. W.] Sejong Univ, Dept Data Sci, Coll Software Convergence, Seoul, South Korea; [Yang, J. M.] Univ Ulsan, Asan Med Ctr, Dept Ophthalmol, Coll Med, Seoul, South Korea; [Ghayda, R. A.] Univ Hosp, Urol Inst, Cleveland, OH USA; [Ghayda, R. A.] Case Western Reserve Univ, Cleveland, OH 44106 USA; [Fusar-Poli, P.] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England; [Fusar-Poli, P.] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy
- 등재 SCIE, SCOPUS
- 발행기관 VERDUCI PUBLISHER
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181468
- 본문언어 영어
- Published As http://dx.doi.org/10.26355/eurrev_202102_24862
초록/요약
OBJECTIVE: Alzheimer's disease (AD) is a leading cause of years lived with disability in older age, and several cerebrospinal fluid (CSF) markers have been proposed in individual meta-analyses to be associated with AD but field-wide evaluation and scrutiny of the literature is not available. MATERIALS AND METHODS: We performed an umbrella review for the reported associations between CSF biomarkers and AD. Data from available meta-analyses were reanalyzed using both random and fixed effects models. We also estimated between-study heterogeneity, small-study effects, excess significance, and prediction interval. RESULTS: A total of 38 meta-analyses on CSF markers from 11 eligible articles were identified and reanalyzed. In 14 (36%) of the meta-analyses, the summary estimate and the results of the largest study showed non-concordant results in terms of statistical significance. Large heterogeneity (I-2=75%) was observed in 73% and smallstudy effects under Egger's test were shown in 28% of CSF biomarkers. CONCLUSIONS: Our results suggest that there is an excess of statistically significant results and significant biases in the literature of CSF biomarkers for AD. Therefore, the results of CSF biomarkers should be interpreted with caution.
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