IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease
- 주제(키워드) Mucocutaneous lymph node syndrome , IgA , Coronary aneurysms
- 주제(기타) Cardiac & Cardiovascular Systems
- 설명문(일반) [Kim, Jae-Jung; Kim, Hea-Ji; Lee, Jong-Keuk] Univ Ulsan, Asan Inst Life Sci, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; [Yu, Jeong Jin] Univ Ulsan, Asan Med Ctr, Dept Pediat, Coll Med, Seoul, South Korea; [Yun, Sin Weon] Chung Ang Univ Hosp, Dept Pediat, Seoul, South Korea; [Lee, Kyung-Yil] Catholic Univ Korea, Dept Pediat, Daejeon St Marys Hosp, Daejeon, South Korea; [Yoon, Kyung Lim] Kyung Hee Univ Hosp Gangdong, Dept Pediat, Seoul, South Korea; [Kil, Hong-Ryang] Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea; [Kim, Gi Beom] Seoul Natl Univ, Dept Pediat, Childrens Hosp, Seoul, South Korea; [Han, Myung-Ki] Univ Ulsan, Gangneung Asan Hosp, Dept Pediat, Kangnung, South Korea; [Song, Min Seob] Inje Univ, Dept Pediat, Paik Hosp, Busan, South Korea; [Lee, Hyoung Doo] Pusan Natl Univ Hosp, Dept Pediat, Busan, South Korea; [Jun, Hyun Ok] Myongji Hosp, Dept Pediat & Adolescent Med, Goyang, South Korea; [Ha, Kee Soo] Korea Univ, Dept Pediat, Guro Hosp, Seoul, South Korea; [Hong, Young Mi] Ewha Womans Univ Hosp, Dept Pediat, Seoul, South Korea; [Jang, Gi Young] Korea Univ, Dept Pediat, Ansan Hosp, Ansan, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC CARDIOLOGY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181480
- 본문언어 영어
- Published As http://dx.doi.org/10.4070/kcj.2020.0345
초록/요약
Background and Objectives: Kawasaki disease (KD) is an acute systemic vasculitis that affects the coronary arteries. Abnormal immune reactions are thought to contribute to disease pathogenesis. The effect of immunoglobulin (Ig) isotype (IgG, IgA, IgM, and IgE) on inflammatory data and clinical outcomes of patients with KD was examined. Methods: Ig levels in 241 patients with KD were measured during the acute, subacute, convalescent, and normal phases of the disease. Results: Compared with reference Ig values, IgG, IgA, and IgM levels were significantly higher in the subacute phase, while IgE levels were elevated in 73.9% (178/241) of patients with KD in all clinical phases. However, high IgE levels were not associated with clinical outcomes, including intravenous immunoglobulin unresponsiveness and coronary artery lesions (CALs). Significantly more CALs were observed in the high IgA group than in the normal IgA group (44.7% vs. 20.8%, respectively; p<0.01). In addition, IgA levels in the acute phase (p=0.038) were 2.2-fold higher, and those in the subacute phase were 1.7-fold higher (p<0.001), in the CAL group than in the non-CAL group. IgA concentrations increased along with the size of the coronary artery aneurysm (p<0.001). Furthermore, there was a strong correlation between IgA levels and CAL size (r=0.435, p<0.001), with a high odds ratio of 2.58 (p=0.022). Conclusions: High IgA levels in patients with KD are prognostic for the risk of CALs.
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