The essential role of TAZ in normal tissue homeostasis
- 주제(키워드) Hippo pathway , TAZ , Tissue homeostasis , Transcriptional control , YAP
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Jeong, Mi Gyeong; Kim, Hyo Kyeong; Hwang, Eun Sook] Ewha Womans Univ, Coll Pharm, C206 Sci Bldg,52 Ewhayeodae Gil, Seoul 03760, South Korea; [Jeong, Mi Gyeong; Kim, Hyo Kyeong; Hwang, Eun Sook] Ewha Womans Univ, Grad Sch Pharmaceut Sci, C206 Sci Bldg,52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181506
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-021-01322-w
초록/요약
Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized in organ development, tissue regeneration, and tumor progression. In particular, TAZ functions as a Hippo mediator that regulates organ size, tumor growth and migration. It is highly expressed in various types of human cancer, and has been reported to be associated with tumor metastasis and poor outcomes in cancer patients, suggesting that TAZ is an oncogenic regulator. Yes-associated protein (YAP) has 60% similarity in amino acid sequence to TAZ and plays redundant roles with TAZ in the regulation of cell proliferation and migration of cancer cells. Therefore, TAZ and YAP, which are encoded by paralogous genes, are referred to as TAZ/YAP and are suggested to be functionally equivalent. Despite its similarity to YAP, TAZ can be clearly distinguished from YAP based on its genetic, structural, and functional aspects. In addition, targeting superabundant TAZ can be a promising therapeutic strategy for cancer treatment; however, persistent TAZ inactivation may cause failure of tissue homeostatic control. This review focuses primarily on TAZ, not YAP, discusses its structural features and physiological functions in the regulation of tissue homeostasis, and provides new insights into the drug development targeting TAZ to control reproductive and musculoskeletal disorders.
more