A Rare Cause of Refractory Severe Polyhydramnios: Antenatal Bartter Syndrome
- 주제(키워드) antenatal Bartter syndrome , polyhydramnios , amniotic fluid , indomethacin
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Nam, Gina] Chung Ang Univ, Chung Ang Univ Hosp, Dept Obstet & Gynecol, Coll Med, Seoul 06973, South Korea; [Cho, Angela] Univ Ulsan, Asan Med Ctr, Dept Obstet & Gynecol, Coll Med, 88,Olympic Ro 43 Gil, Seoul 05505, South Korea; [Park, Mi-Hye] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181507
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/medicina57030272
초록/요약
Background: Antenatal Bartter syndrome is an autosomal recessive disorder causing severe polyuria that leads to severe polyhydramnios and preterm labor. Prenatal diagnosis of antenatal Bartter syndrome is difficult because the genetic diagnosis can only be confirmed following a clinical diagnosis in infants. Reports of prenatal diagnosis and treatment of antenatal Bartter syndrome are limited. Case Presentation: We present the case of a 33-year-old pregnant woman with refractory polyhydramnios at 31 weeks of gestation. There were no structural anomalies or placental problems on ultrasonography; therefore, antenatal Bartter syndrome was suspected. With repeated amniocentesis and indomethacin therapy, the pregnancy continued to 36 weeks of gestation. The clinical features of the infant and subsequent genetic testing confirmed the diagnosis of antenatal Bartter syndrome. The baby was in good clinical condition at the 3-month follow-up visit. Conclusions: For pregnant women with early onset and refractory severe polyhydramnios without morphological anomalies, antenatal Bartter syndrome should be highly suspected.
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